Amino - PEG12 - Acid Is A Kind Of PEG Contaning An Amine Group
|Transparent and oil free liquid|
|-20℃ for Long Term|
The Amino - PEG12 - Acid is used for modifying proteins or surfaces
such as beads, nanoparticles and self-assembled monolayers.
Modification of proteins adds polyethylene glycol (PEG)n spacers, which impart increased water solubility, reduced
immunogenicity of the labeled molecule and enhanced in vivo stability in solution. Functionalization of solid surfaces, such
as quantum dots, self-assembled monolayers and nanoparticles, with
polyethylene glycol spacers significantly reduces nonspecific
protein binding. (PEG)n amine reagents used with (PEG)n amine
reagents in surface modification can form a hydrophilic “lawn” of
methyl ether-terminated PEGs with periodic exposed
carboxy-terminated PEGs. The exposed carboxy groups can be coupled
to affinity ligands using the carbodiimide coupling reaction with
EDC and sulfo-NHS.
Typical PEGylation reagents contain heterogeneous mixtures of
different PEG chain lengths; however, our PEGylation reagents are
homogenous compounds of defined molecular weight and spacer length,
providing precision in optimizing modification applications.
Important Product Information
• The Amino - PEG12 - Acid is low-melting solids that are difficult
to weigh and dispense. To facilitate handling, make a stock
solution by dissolving the reagent with dimethylsulfoxide (DMSO) or
• Use the (PEG)n amine reagents in combination with (PEG)n amine
reagents to modify surfaces and minimize nonspecific binding.
• Use non-amine-containing buffers at pH 7-9 such as PBS (20mM
sodium phosphate, 150mM NaCl; pH 7.4); 20mM HEPES; 100mM
carbonate/biocarbonate; or 50mM borate. Do not use buffers that
contain primary amines, such as Tris or glycine, which compete with